Tiger Woods and 2013 U.S. Open champion Justin Rose were among four players that tied for second, while 2005 runner-up Jim Furyk and Phil Mickelson were two strokes off the pace.
Scott birdied the 16th last year to gain a share of the lead. He parred the last two holes, then watched as his competitors failed to match his 11-under par total.
Kevin Chappell lost his share of the lead with a bogey on No. 13. Woodland also bogeyed the 13th to lose his piece of the lead. Rose was up next.
Rose went to the 18th tied with Scott atop the leaderboard. However, Rose missed a 5-foot par putt to end one back.
Woods had a chance after birdies at 16 and 17, but Woods failed to make a 19- footer for birdie at the last. Finally, Woodland had the last chance, but he missed a 10-foot birdie effort.
Scott is back to defend his title, that he won at Liberty National last year. The field he will battle this week includes 122 of the 125 from the FedExCup points list.
Dustin Johnson is on a leave of absence from the tour and Jason Dufner is battling a pair of bulging discs in his neck. Also, Steve Stricker is skipping the event, for the second straight year, to spend time with his family.
World No. 1 Rory McIlroy stands atop the points list by 89 points entering the playoffs. Including this week's tournament, Hunter Mahan stands as the only player to compete in all 29 FedExCup playoff events. Mahan, Stricker and Mickelson are the only three that have made it to the Tour Championship in the seven seasons of the FedExCup.
Golf channel will have coverage all four days and will hand things off to CBS in the afternoon on Saturday and Sunday.
The playoffs continue next week outside of Boston with the Deutsche Bank Championship, where Henrik Stenson closed 66-66 last year to come from behind and win the title by two strokes over Stricker.
D+D REAL CZECH MASTERS, Albatross Golf Resort, Prague, Czech Republic - The European Tour has its second straight new event this week with the D+D Real Czech Masters.
This will be the first European Tour event played in the Czech Republic since 2011.
This event is the penultimate event for earning points towards the European Ryder Cup team. Jamie Donaldson, Stephen Gallacher and Joost Luiten are among those battling for a spot on that team, and they will headline the field this week at Albatross Golf Resort.
Bernd Wiesberger, who played in the final group at the PGA Championship with eventual winner Rory McIlroy, returns to action this week as well.
Golf Channel will have coverage all four days.
The European Tour heads to Italy next week for the Italian Open. Julien Quesne closed with a 5-under 67 last year to rally and win for the second time on the European Tour.
CANADIAN PACIFIC WOMEN'S OPEN, London Hunt and Country Club, London, Ontario - Lydia Ko made more history at the Canadian Pacific Women's Open in 2013 as she repeated as the champion.
Ko won the 2012 and 2013 titles as an amateur. In 2012, Ko opened 68-68 to put herself in contention. After a third-round 72, she closed with a 67 to beat Inbee Park by three strokes and become the youngest winner in LPGA Tour history and she became the first amateur winner since JoAnne Carner in 1969.
The teenager followed that up with a big win last year. Ko fired a 6-under 64 in the final round at Royal Mayfair Golf Club in Edmonton last year to cruise to a 5-stroke win over Karine Icher.
The event returns to London Hunt and Country Club, where Cristie Kerr won the title in 2006.
Golf Channel will have coverage of all four rounds.
The LPGA Tour heads to the west coast next week for the Portland Classic. Suzann Pettersen fired a 67 in the final round last year to fend off Stacy Lewis for her 12th LPGA Tour title.
BOEING CLASSIC, TPC Snoqualmie Ridge, Snoqualmie, Washington - The Champions Tour moves to the west coast this week for the Boeing Classic.
Last year, John Riegger fired a 64 in the second round to grab the lead. Then, he closed with a 4-under 68 to claim his first tour title. The win came in Riegger's fifth tour start.
Riegger is coming off just his second top-10 finish of the season last week in New York. He shared seventh place there. He made the cut in four of the five majors this season, with a tie for 12th at the Senior Players Championship being his best finish.
Seattle native Fred Couples will headline the field near his hometown. He headlines the field that includes five of the top 10 in the Charles Schwab Cup race and six of the top 10 money leaders.
Bernhard Langer, who tops both those lists, will also be at TPC Snoqualmie Ridge. Last week, Langer won for the fifth time this season at the Dick's Sporting Goods Open.
Golf Channel will have coverage of all three days of this event, which begins on Friday.
The Champions Tour heads north of the border next week for the first of two straight events in Canada. First up is the Shaw Charity Classic. Rocco Mediate blitzed the field there last year, as he went 63-64-64 to win by seven strokes over Tom Byrum.
WINCO FOODS PORTLAND OPEN, Witch Hollow at Pumpkin Ridge, North Plains, Oregon - The Web.com Tour heads to Oregon for the final regular season event of 2014. This is the last chance for players to qualify for the four-event Web.com Tour finals.
The top 25 on the money list after the Portland Open will earn their PGA Tour cards for the 2014-15 season. The top 75 on the money list will gain entry into the tour finals, which will provide another 25 PGA Tour cards for next season at the end of the four events.
Every player in the top 10 on the money list is in the field this week, while everyone ranked 20-30 on the money list will also be at Witch Hollow at Pumpkin Ridge.
The busy Golf Channel will have coverage of all four rounds this week.
The Web.com Tour finals series kicks off next week in Indiana with the Hotel Fitness Championship. Former Masters champion Trevor Immelman won that title last year thanks to a closing 66.
PGA TOUR CANADA
THE GREAT WATERWAY CLASSIC, Loyalist Golf & Country Club, Kingston, Ontario - The PGA Tour Canada is in Ontario for the second of three straight events in that province.
Hugo Leon closed with a 5-under 67 last year to earn his second victory on the PGA Tour Canada. Leon birdied two of the last three holes to edge Brandon Harkins, who fired a 10-under 62 in the final round.
There are just three remaining on the tour schedule after this. Players are battling to finish in the top five on the Order of Merit, which will give them Web.com Tour status for next year.
Eighteen of the top-20 players from the Order of Merit are in the field this week, with William Kropp and Jeff Corr being the only two skipping the event.
The PGA Tour Canada wraps up its stay in Ontario next week with the Wildfire Invitational. Mark Hubbard beat Kyle Stough by two strokes last year to earn his first tour title.