WebMD Medical News
Louise Chang, MD
March 3, 2008 -- New information about a possible genetic cause of celiac
disease could soon lead to better treatments for the immune disorder.
Researchers have identified a group of seven gene regions that appear to
predispose people to celiac disease.
People with celiac disease cannot tolerate gluten protein found in wheat, rye, and barley products, such
as breads and cereals. They must follow a strict gluten-free diet to control
their symptoms, which can include abdominal pain, fatigue, and weight loss.
When people with celiac disease eat foods containing gluten, their immune
systems attack the protein. This damages the intestinal lining, hampering the
ability to absorb vital nutrients from food, eventually leading to
Celiac disease affects up to 1% of the population and is difficult to treat
and diagnose. Researchers say a better understanding of what causes the immune
system disorder could lead to improved treatments for the condition.
Previous studies identified a genetic region on chromosome four associated
with celiac disease. In this study, the same research group identified seven
new genetic regions associated with an increased risk of celiac disease.
Researchers compared genetic markers in people with and without celiac
disease and then assessed about 1,000 of the strongest markers in a further
The results, published in Nature Genetics, identified seven new
genetic risk regions associated with celiac disease. Of those seven mutations,
six involve genes that control immune responses.
"So far, our findings explain nearly half of the heritability of celiac
disease -- now studies with many more samples from individuals with celiac
disease are needed to identify the precise causal genetic variants from each
region, and understand how these influence biological processes," researcher
David van Heel, professor of gastrointestinal genetics at Barts and the London
School of Medicine and Dentistry, says in a news release.
SOURCES:Hunt, K. Nature Genetics, March 2, 2008 advance online edition.News release, Queen Mary, University of London.
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